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In November 333 BC, the Macedonian troops led by Alexander the Great, outnumbered roughly by four to one, defeated the army led by Darius III of Persia in the Battle of Issus. 公元前三三三年十一月， 亞歷山大大帝率領馬其頓部隊， 大約以一敵四， 擊敗大流士三世統領的波斯軍。